SPATIAL DOWNREGULATION OF CD74 SIGNATURES MAY DRIVE INVASIVE COMPONENT DEVELOPMENT IN PART-SOLID LUNG ADENOCARCINOMA

Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma

Summary: Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma.To define the spatial composition and evolutionary trajectories of early-stage lung adenocarcinoma, we combined spatial transcriptomics (ST) and pathological annotations from 20 part-solid nodules (PSNs), four

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Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up

The objective of this study is to report the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in three patients GD001 with medication-refractory Tourette syndrome (TS) and over 3-month follow-up.A review of literature on the use of rTMS for the treatment of TS is also presented.Three patients with severe, medication-refr

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